Nano-particles's influence on the body vary due to the immune characteristics

Recently, the international magazine Nanotechnologies, in. Russia published the latest research results of Russian researchers Acute immune response to the intranasal application of nanoparticles of SiO2 (Tarkosil 25) in mice. Of two strains of. "Article, the researchers revealed the nano-particles on body influence the immune characteristics vary.

With the continuous development of nanotechnology, the opportunities for human exposure to nanoparticles gradually increased. For the study of the impact of particles on the body, the Russian researchers conducted experiments on mice, the results found that nanoparticles can cause mice, leukocytosis, its extent and impact of different immune characteristics in mice and different.

Cells of the Russian Academy of Sciences and Institute of Genetics, animal classification and Physiology, Institute of experts in the new one Russian academic journal "Russian Nanotechnology reported that they will size smaller than 100 nanometers (a nanometer is equal to millionths mm) of silica particles selected as the object of study, this substance is often used as filler material in the production of rubber products, cosmetics and pharmaceutical process or the catalyst composition.

Russian researchers selected two mice, the prominent features of mice A "cellular immunity", and that their immune T cells directly against the ability of the pathogen. B mice humoral immune capacity known, that their B cells to produce antibodies and to guide the immune response than outstanding.

Researchers A and B two kinds of mice were divided into three groups, each group seventy-eight. The nose of each mouse in Group A, instillation of 25 edged up suspension, the silica particle size less than 100 nm. Group B mice nasal intake of silica particles over 100 nm. Group C instillation of physiological solution. After four hours, investigators extract blood samples of each group of mice and the inner surface of the lungs and bronchial swabs.

The analysis showed that the inhalation of silica particles resulting in mice A number of blood test values ​​to change, including the WBC count was significantly increased. B mice not only leukocytosis, and the lungs against inflammation in the early immune response. Compared with the silica particles of respirable size over 100 nm, this is less than 100 nm particles impact on the immune system significantly much more.